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Malaria kills off the majority of European colonists in the Carolinas, leading to the expansion of enslavement.

1750

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Eighty-six percent of white children die before they reach the age of 20. There is a common English proverb at the time: "Those who want to die quickly, go to Carolina." The majority of enslaved Africans carry some form of immunity, such as the sickle cell gene or other traits that increase their resistance to malaria. Planters in the West Indies and the Carolinas agree to pay three times as much for an enslaved African as an indentured European servant, as a result of their likelihood of surviving malaria.